Hagit Eldar-Finkelman Selected Research

Glycogen Synthase (Synthase I)

1/2017	Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.
11/2016	A unique type of GSK-3 inhibitor brings new opportunities to the clinic.
9/2013	GSK-3 and lysosomes meet in Alzheimer's disease.
7/2013	GSK-3 inhibition: achieving moderate efficacy with high selectivity.
5/2013	Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
1/2013	Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies.
5/2012	Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.
1/2011	GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS.
4/2007	Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury.
1/2006	Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle.

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Hagit Eldar-Finkelman Research Topics

Disease

9	Type 2 Diabetes Mellitus (MODY) 08/2010 - 03/2002
8	Insulin Resistance 08/2010 - 07/2002
7	Alzheimer Disease (Alzheimer's Disease) 11/2016 - 03/2002
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 04/2006
3	Cognitive Dysfunction 01/2017 - 01/2013
3	Neoplasms (Cancer) 11/2016 - 05/2007
2	Central Nervous System Diseases (CNS Diseases) 11/2016 - 01/2011
2	Mental Disorders (Mental Disorder) 07/2013 - 01/2011
2	Bipolar Disorder (Manic Depressive Psychosis) 01/2004 - 03/2002
1	Huntington Disease (Huntington's Disease) 01/2021
1	Tuberous Sclerosis (Bourneville's Disease) 01/2020
1	Fragile X Syndrome (Martin Bell Syndrome) 01/2017
1	Inflammation (Inflammations) 11/2016
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 05/2013
1	Colorectal Neoplasms (Colorectal Cancer) 05/2012
1	Bites and Stings (Sting) 05/2012
1	Cardiovascular Diseases (Cardiovascular Disease) 05/2012
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/2012
1	Nervous System Diseases (Neurological Disorders) 01/2011
1	Pancreatic Neoplasms (Pancreatic Cancer) 05/2010
1	Mood Disorders (Mood Disorder) 03/2010
1	Brain Concussion (Cerebral Concussion) 04/2007
1	Brain Injuries (Brain Injury) 04/2007
1	Body Weight (Weight, Body) 01/2006
1	Hyperglycemia 01/2006
1	Craniocerebral Trauma (Head Injury) 03/2002
1	Stroke (Strokes) 03/2002

Drug/Important Bio-Agent (IBA)

15	Glycogen Synthase Kinase 3IBA 01/2021 - 03/2002
15	Glycogen Synthase (Synthase I)IBA 01/2017 - 07/2002
5	Insulin (Novolin)FDA Link 01/2017 - 07/2002
4	Pharmaceutical PreparationsIBA 11/2016 - 10/2002
3	Amyloid (Amyloid Fibrils)IBA 11/2016 - 01/2013
2	TOR Serine-Threonine KinasesIBA 01/2021 - 01/2013
2	Biological ProductsIBA 01/2011 - 08/2010
2	Glucose (Dextrose)FDA LinkGeneric 08/2010 - 01/2006
2	Insulin Receptor Substrate ProteinsIBA 02/2005 - 10/2002
2	LithiumIBA 01/2004 - 03/2002
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 09/2003 - 07/2002
1	trans-sodium crocetinate (crocetin)IBA 01/2020
1	Histones (Histone)IBA 01/2017
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2010
1	Proteins (Proteins, Gene)FDA Link 08/2010
1	Lithium ChlorideIBA 05/2010
1	Glycogen Synthase Kinase 3 betaIBA 05/2010
1	Phosphotransferases (Kinase)IBA 05/2010
1	beta CateninIBA 05/2010
1	N- myristoyl- glycyl- lysyl- glutamyl- alanyl- prolyl- prolyl- alanyl- prolyl- prolyl- glutaminyl- phosphoseryl- prolineIBA 01/2006
1	Blood Glucose (Blood Sugar)IBA 01/2006
1	Protein Kinases (Protein Kinase)IBA 09/2003
1	CationsIBA 07/2002
1	ZincIBA 07/2002
1	EnzymesIBA 03/2002
1	Valproic Acid (Depakote)FDA LinkGeneric 03/2002

Therapy/Procedure

2	Therapeutics 05/2007 - 01/2006
1	Drug Therapy (Chemotherapy) 05/2010